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KMID : 0613320130190020056
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Journal of the Korean Bone and Joint Tumor Soceity
2013 Volume.19 No. 2 p.56 ~ p.63
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Early Result of Demineralized Bone Matrix (DBM, Genesis®) in Bone Defect after Operative Treatment of Benign Bone Tumor
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Seo Hyun-Je
Jung So-Hak
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Abstract
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Purpose: This study was performed to evaluate the efficiency of demineralized bone matrix (DBM, Genesis®) used for bone defectafter operative traetment of benign bone tumors by clinical and radiological methods.
Materials and Methods: DBM was used to treat bone defect after operative treatment of benign tumor from February 2012 to May2013. Total 25 benign bone tumor cases (15 males, and 10 females) with mean age of 30.3 were studied. The diagnoses were solitarybone cyst in 9 cases, non ossifying fibroma in 5, fibrous dysplasia in 5, aneurysmal bone cyst in 3 and enchondroma in 3. In categorizationby location of tumor, there were 5 cases of distal femur, 4 of proximal tibia, 3 of proximal femur, 3 of proximal humerus, 3 ofphalanx, 2 of distal radius, 2 of hip bone, 2 of calcaneus, and 1 of scapula. Autogenous bone was used with DBM in 6 cases, and onlyDBM used in 19 cases. Mean periods of follow up were 8.7 months (range: 6 to 14 months). Amount of graft resorption and bone formationwas observed with compare of post operation radiograph and the difference was shown by percentage. Resorption level wasmeasured by DBM level which could be observed from simple x-ray, and bone formation level by bone trabecular formation level atimpaired site.
Results: Twenty three cases of total 25 cases showed bone union. In the 23 cases, more than 98% DBM resorption was observedafter mean 4.3 months, and more than 98% bone formation was observed after mean 6.9 months. Lesser bone defect sizes showedfaster bone formation and it was statistically significant (p=0.036). But other comparative studies on other factors such as, sex, ageof patients and combination of autogenous bone were no statistically significant differences in graft resorption and bone formation.And there was no significant complication in periods of follow-up.
Conclusion: Demineralized Bone Matrix (Genesis®) is thought to be useful treatment for bone defect after operative treatment ofbenign bone tumor, however longer follow-up periods appears to be needed.
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KEYWORD
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benign bone tumor, Demineralized Bone Matrix
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